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Updated: May 22, 2026

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
Published on: February 17, 2023
Atypical polypoid adenomyomas progressed to endometrial endometrioid adenocarcinomas
Hong Kai Zhang1, Wei Dong Chen
1Department of Pathology, Beijing Fuxing Hospital affiliated to the Capital University of Medical Sciences, Beijing Fuxing Menwai Street #20, Beijing, 100038, China. zhk0484@sina.com.cn
Introduction:
Atypical polypoid adenomyoma (APA) is an uncommon uterine tumor which is composed of atypical endometrial glands and cellular smooth-muscle stroma. At present APA is categorized as a benign lesion and treated conservatively in the literatures. However, there are also several cases reported that progressed to endometrial endometrioid adenocarcinoma (EEC) till now. Here, we present two more rare cases of APA that may have undergone progression to EEC.
Materials:
Two patients who had APA 6 and 4 years ago, respectively, and had ECC were reported.
Methods:
The history of the two patients and the literatures were retrospectively reviewed.
Conclusions:
The truth that APA may have a chance to progress to carcinoma suggests that APA is at least an indicator lesion for the development of EEC, and highlights that clinicians should carefully monitor the patients, and a meticulous follow-up examination is mandatory.
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