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Updated: May 22, 2026
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Conjunctival squamous cell carcinoma requiring orbital exenteration: case report]
Larissa Horikawa Satto1, Mariangela Esther Alencar Marques, Silvana Artioli Schellini
1Setor de Plástica Ocular, Departamento de Oftalmologia, Faculdade de Medicina, Universidade Estadual de São Paulo, Botucatu, Brazil.
Arquivos Brasileiros De Oftalmologia
|May 4, 2012
Summary
Squamous cell carcinoma of the conjunctiva can recur after surgical removal. Adjuvant 5-Fluorouracil treatment showed an unfavorable outcome, necessitating orbital exenteration in this case.
Area of Science:
- Ophthalmology
- Oncology
- Surgical Pathology
Background:
- Conjunctival squamous cell carcinoma (SCC) is a malignant epithelial tumor.
- Early diagnosis and complete surgical excision are crucial for optimal outcomes.
- Adjuvant therapies are sometimes employed to reduce recurrence risk.
Observation:
- A case of conjunctival SCC is presented.
- The initial lesion was surgically removed but recurred at a new site.
- The patient underwent adjuvant treatment with 5-Fluorouracil (5-FU).
Findings:
- Despite surgical removal and 5-Fluorouracil treatment, the tumor exhibited unfavorable evolution.
- The aggressive nature of the recurrence necessitated a more extensive surgical procedure.
- Orbital exenteration was ultimately required due to disease progression.
Implications:
- This case highlights the potential for aggressive behavior and recurrence of conjunctival SCC.
- The efficacy of antimitotic drugs like 5-Fluorouracil as adjuvant therapy warrants further investigation.
- Management strategies for recurrent or advanced conjunctival SCC may need re-evaluation.
