Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing

Xiao Xiao Tang1, Kin Lam Fok, Hao Chen

  • 1Epithelial Cell Biology Research Center, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, HKSAR, Hong Kong, China.

Summary

Lymphocytes expressing cystic fibrosis transmembrane conductance regulator (CFTR) enhance lung epithelial bicarbonate secretion and bacterial defense. This CFTR-dependent interaction is crucial for innate immunity against respiratory infections.

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