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Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection

Martha J Lewis1, Mirabelle Dagarag, Basim Khan

  • 1Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA. malewis@mednet.ucla.edu

Journal of Virology
|May 4, 2012
PubMed

Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."

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