Related Experiment Video
Updated: May 22, 2026
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
5-hydroxytryptamine level and 5-HT2A receptor mRNA expression in the guinea pigs eyes with spectacle lens-induced
Ji-Wen Yang1, Yan-Chun Xu, Lin Sun
1Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
Aim:
To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM).
Methods:
Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye).
Results:
LIM eyes formed significant myopia with longer axial length. 5-HT level in retina, choroids and sclera from LIM eyes was significantly higher than that in control group. 5-HT2A mRNA expression was also significantly up-regulated.
Conclusion:
Refraction lens could induce myopia in guinea pig and 5-HT may play an important role in the formation of myopia by binding with 5-HT2A receptor.
