Endogenous aspergillus endophthalmitis after kidney transplantation

Area of Science:

• Ophthalmology
• Nephrology
• Infectious Diseases

Background:

• Endogenous aspergillus endophthalmitis (EAE) is a rare but serious complication following kidney transplantation.
• Traditional treatments like amphotericin B pose risks, especially for patients with renal impairment.

Purpose of the Study:

• To report a successful treatment modality for EAE in a kidney transplant recipient.
• To emphasize the importance of early diagnosis and multimodal therapy.

Main Methods:

• Diagnosis involved fundoscopy, B-scan ultrasound, and vitreous culture.
• Treatment included vitrectomy, systemic micafungin and voriconazole, and topical fluconazole and amphotericin B.

Main Results:

• Successful control of EAE was achieved through the combined therapeutic approach.
• The patient tolerated the treatment regimen without significant adverse events.

Conclusions:

• Prompt diagnosis and aggressive management, including vitrectomy and a combination of systemic and topical antifungals, are crucial for successful EAE treatment in kidney transplant patients.
• This case demonstrates a viable alternative treatment strategy for EAE in immunocompromised patients with renal compromise.