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Updated: May 22, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
Flecainide suppresses defibrillator-induced storming in catecholaminergic polymorphic ventricular tachycardia
Robert A Hong1, Kahealani K Rivera, Arksarapuk Jittirat
1The Queen's Medical Center, John A. Burns School of Medicine, Department of Internal Medicine, Division of Cardiology John A. Burns School of Medicine, Department of Internal Medicine, Honolulu, Hawaii 96813, USA.
Abstract:
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition associated with ventricular tachycardia (VT) triggered by exercise or sympathetic stress. Incessant VT may develop due to defibrillator-induced storming-a condition where implantable cardioverter-defibrillator discharges result in a hyperadrenergic state, provoking further VT and defibrillator discharge. We describe the case of a 14-year-old boy with CPVT caused by a calsequestrin-2 mutation, who presented with defibrillator-induced storming refractory to β-blockers, calcium-channel blockers, amiodarone, and dronedarone. Flecainide and β-blocker use suppressed incessant VT and defibrillator-induced storming.
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