Related Experiment Video
Updated: May 22, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Tricyclic antidepressant overdose necessitating ICU admission
Coenraad F N Koegelenberg1, Zirkia J Joubert, Elvis M Irusen
1Department of Medicine, University of Stellenbosch. coeniefn@sun.ac.za
Abstract:
Tricyclic antidepressant (TCA) overdose necessitating intensive care unit (ICU) admission remains a significant problem in the Western Cape. In this retrospective study, we reviewed the course of life-threatening TCA overdose in our centre to identify potential prognostic indicators. TCA levels >1000 ng/ml were associated with QT and QRS prolongation and convulsions. However, no single parameter predicted non-survival. The overall mortality of TCA overdose was very low. Our findings should encourage clinicians to offer medical care including ICU admission, if necessary, to patients with TCA overdose.
Related Concept Videos
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Toxidromes: Clinical Features
Pharmaceutical Poisoning: Treatment Strategies
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Acute Coronary Syndrome IV: Interprofessional Care
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
