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Elevated serum levels of Vitamin D in infants with urolithiasis

Mohammad Hossein Fallahzadeh1, Javad Zare, Ghamar Hosseini Al-Hashemi

  • 1Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Iranian Journal of Kidney Diseases
|May 5, 2012
PubMed

Insights

Infants with urolithiasis had significantly higher serum vitamin D levels than controls. This suggests high vitamin D may contribute to infant kidney stones, especially in those with hypercalcemia.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Urology

Background:

  • The causes of infant urolithiasis are not well understood.
  • This study explores a potential link between vitamin D levels and kidney stone formation in infants.

Purpose of the Study:

  • To investigate if infants with urolithiasis have elevated serum vitamin D levels compared to healthy infants.
  • To identify potential risk factors for kidney stone development in infants.

Main Methods:

  • A case-control study involving 36 infants with urolithiasis and 36 matched controls.
  • Analysis of serum and urine samples for various biochemical markers, including 25-hydroxyvitamin D3, calcium, and citrate.

Main Results:

  • Infants with urolithiasis showed significantly higher serum 25-hydroxyvitamin D3 levels (33.85 ± 14.78 ng/mL) compared to controls (18.26 ± 7.43 ng/mL).
  • Twenty-five percent of infants with urolithiasis had hypercalcemia, and 16.7% had hypocitraturia.
  • Nineteen infants (52.8%) with urolithiasis presented with at least one metabolic abnormality.

Conclusions:

  • Elevated serum vitamin D may be a significant factor in infant urolithiasis, particularly in cases involving hypercalcemia.
  • Routine assessment of vitamin D levels is recommended for infants diagnosed with kidney stones.
Abstract

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