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The power and pitfalls of IL-12
Sid P Kerkar1, Nicholas P Restifo
1National Heart, Lung, & Blood Institute, and National Cancer Institute.
Blood
|May 5, 2012
Abstract:
In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2,3
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