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Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent with acute myocardial infarction

A Doğan1, A Icli, E Varol

  • 1Department of Cardiology, Medical School, Suleyman Demirel University, Isparta, Turkey. adogan35@hotmail.com

Cardiovascular Journal of Africa
|May 5, 2012
PubMed

Insights

This study highlights a rare case of acute myocardial infarction with ST-segment elevation in an adolescent. Multiple prothrombotic gene variations were identified, suggesting a potential genetic link in adolescent STEMI.

Area of Science:

  • Cardiology
  • Genetics
  • Thrombosis

Background:

  • Acute myocardial infarction with ST-segment elevation (STEMI) is uncommon in adolescents.
  • The underlying causes of STEMI in this age group are not well understood.
  • A prothrombotic state is increasingly linked to acute STEMI.

Observation:

  • A case of adolescent STEMI with normal coronary arteries is presented.
  • The patient exhibited catheter-induced coronary artery spasm.
  • Multiple prothrombotic genetic polymorphisms were identified.

Findings:

  • The adolescent patient possessed polymorphisms in beta fibrinogen, methylenetetrahydrofolate reductase, and cholesteryl ester transfer protein genes.
  • Genotypes for plasminogen activator inhibitor-1 and human platelet antigen type-1 were also noted.
  • These genetic factors may contribute to a prothrombotic state.

Implications:

  • Prothrombotic genetic factors may play a role in the pathogenesis of adolescent STEMI.
  • Understanding these genetic predispositions could inform future risk assessment and prevention strategies.
  • Treatment involved a calcium antagonist and aspirin for catheter-induced spasm.

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