In vitro studies on thyrogenic effect of commiphora mukul (guggulu).
A K Singh1, G C Prasad, S N Tripathi
1Department of Shalakya, Institute of medical Sciences, Banaras Hindu University, Varanasi - 221005 India.
Ancient Science of Life
|May 5, 2012
Summary
Commiphora mukul extract boosts thyroid function, increasing iodine uptake and thyroid hormone levels. Melatonin inhibits these effects, but Commiphora mukul can counteract melatonin
Area of Science:
- Endocrinology and Pharmacology
- Thyroid Gland Physiology
Background:
- Thyroid hormones regulate metabolism; imbalances can lead to disorders like hypothyroidism.
- Commiphora mukul and melatonin are natural compounds with potential endocrine effects.
Purpose of the Study:
- To investigate the effects of Commiphora mukul (C. mukul) and melatonin on thyroid gland activity in vitro.
- To determine if C. mukul can counteract the inhibitory effects of melatonin on thyroid function.
Main Methods:
- Cultivation of thyroid gland explants in media containing petroleum ether extract of C. mukul.
- Cultivation of thyroid explants in media containing melatonin.
- Cultivation of thyroid explants in media containing both melatonin and C. mukul extract.
- Measurement of iodine-131 (I(131)) uptake, T(3) resin uptake, protein-bound iodine, and free thyroxine index.
Main Results:
- Petroleum ether extract of C. mukul significantly increased thyroid I(131) uptake and thyroid hormone indicators.
- Melatonin significantly decreased thyroid I(131) uptake and thyroid hormone indicators.
- C. mukul extract antagonized the inhibitory effects of melatonin on thyroid function.
Conclusions:
- Commiphora mukul extract demonstrates potential in managing hypothyroidism and related conditions like hypercholesterolemia.
- C. mukul may possess thyroid-stimulating properties, while melatonin exhibits inhibitory effects.
- Combined use suggests C. mukul could mitigate melatonin-induced thyroid suppression.
