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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

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Updated: May 22, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

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Published on: April 23, 2021

P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.

P Kochunov1, D C Glahn, L E Hong

  • 1Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine Baltimore, MD, USA.

Frontiers in Genetics
|May 5, 2012
PubMed
Summary
This summary is machine-generated.

Elevated P-selectin gene expression is linked to reduced brain integrity and may indicate hypertension-related cerebral atrophy risk. This finding highlights P-selectin

Keywords:
DTIP-selectinagingcerebral atrophygene expressiongeneticshypertension

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Area of Science:

  • Genetics
  • Neuroimaging
  • Cardiovascular Disease

Background:

  • The P-selectin (SELP) gene on chromosome 1q24 is investigated for its potential role in blood pressure and brain health.
  • Previous research suggests a link between genetic factors and cerebral integrity.

Purpose of the Study:

  • To test the hypothesis that the SELP gene pleiotropically contributes to increased blood pressure and cerebral atrophy.
  • To analyze genetic correlations between SELP gene expression and markers of cerebral integrity.

Main Methods:

  • Genetic correlation analyses were performed on 13 mRNA gene expressions and three MRI-derived indices of cerebral integrity.
  • The study included 369 normally aging Mexican-American family members.
  • Measurements included leukocyte-based mRNA gene expressions, cortical gray matter thickness, white matter fractional anisotropy, and white matter lesion volume.

Main Results:

  • Significant phenotypic correlations were observed for P-selectin and L-selectin expression levels.
  • Increased P-selectin expression correlated with decreased cerebral integrity, driven by shared genetic factors.
  • L-selectin expression showed an inverse trend, linked to shared environmental effects.

Conclusions:

  • P-selectin expression shares significant variance with cerebral integrity measurements.
  • Elevated P-selectin levels are proposed as a potential risk factor for hypertension-related cerebral atrophy.