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The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

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Related Experiment Video

Updated: May 22, 2026

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain
09:29

Stereotactically-guided Ablation of the Rat Auditory Cortex, and Localization of the Lesion in the Brain

Published on: October 11, 2017

Auditory cortex basal activity modulates cochlear responses in chinchillas.

Alex León1, Diego Elgueda, María A Silva

  • 1Laboratorio de Neurobiología de la Audición, Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Plos One
|May 5, 2012
PubMed
Summary
This summary is machine-generated.

Auditory cortex activity influences cochlear responses via efferent pathways. Blocking this activity altered cochlear microphonics and auditory nerve potentials, suggesting a basal efferent tone regulating hearing.

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Behavioral Determination of Stimulus Pair Discrimination of Auditory Acoustic and Electrical Stimuli Using a Classical Conditioning and Heart-rate Approach
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Area of Science:

  • Neuroscience
  • Auditory System Research
  • Sensory Neuroscience

Background:

  • The auditory efferent system connects the cerebral cortex to sensory receptors via unique neuroanatomical pathways.
  • Descending projections from the auditory cortex influence auditory nuclei and the cochlear receptor through the olivocochlear system.
  • The precise function of the cortico-olivocochlear efferent system is not fully understood.

Purpose of the Study:

  • To investigate the hypothesis that auditory cortex basal activity modulates cochlear and auditory-nerve afferent responses via the efferent system.
  • To elucidate the role of the cortico-olivocochlear efferent system in auditory processing.

Main Methods:

  • Recorded cochlear microphonics (CM), auditory-nerve compound action potentials (CAP), and auditory cortex evoked potentials (ACEP) in anesthetized chinchillas.
  • Deactivated the auditory cortex using lidocaine microinjections or cortical cooling.
  • Analyzed changes in CM, CAP, and ACEP amplitudes before, during, and after auditory cortex deactivation.

Main Results:

  • Auditory cortex deactivation led to significant changes in CM and CAP amplitudes, with a common effect being a decrease in CM.
  • Concomitant changes in CAP included both increases and reductions in amplitude.
  • While auditory cortex evoked potentials recovered, cochlear responses showed only partial recovery after deactivation.

Conclusions:

  • Blocking auditory cortex activity modulates cochlear and auditory nerve responses, indicating a basal efferent tone.
  • Cortico-olivocochlear circuits actively regulate auditory nerve and cochlear responses.
  • The varied effects suggest the existence of at least two distinct functional pathways from the auditory cortex to the cochlea.