Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

Personalized Music-Embedded Sound Therapy Based on Gating Modulation and Neural Decoupling Reduces Tinnitus Severity.

Pablo I Henriquez¹, Paul H Delano^1,2,3,4, Javiera Herrada¹

¹Department of Otolaryngology, Hospital Clínico Universidad de Chile, Santiago 8380456, Chile.

|June 26, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β<sub>2</sub>-adrenergic receptor expression.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Superficial and deep white matter brain alterations discriminate tinnitus in older adults.

Brain structure & function·2026

Same author

Telehealth cochlear implant programming in Chile yields outcomes comparable to in-person clinical care.

Medwave·2026

Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Increased basal ganglia volume in older adults with tinnitus.

Scientific reports·2025

Same author

Dissecting the Interactions of Diabetes Mellitus and Hearing Loss with Cognitive Decline and Dementia.

Brain sciences·2025

Same journal

Anterior Cingulate Cortex Mediates State-Dependent Prioritization of Distressed Conspecifics.

Brain sciences·2026

Same journal

Hemispherotomy for Pediatric Post-Traumatic Epilepsy.

Brain sciences·2026

Same journal

When Robots Learn: Artificial Intelligence and the Next Human-Centered Era of Neurorehabilitation.

Brain sciences·2026

Same journal

The Association Between Changes in White Matter Microstructure and Cognitive Function in Older Adults with Mild Cognitive Impairment.

Brain sciences·2026

Same journal

Beyond Ventricular Enlargement: Multimodal MRI Assessment Improves Surgical Decision-Making in Normal Pressure Hydrocephalus.

Brain sciences·2026

Same journal

The Effects of Personalized Observation, Execution, and Mental Imagery (POEM) Therapy in Logopenic Primary Progressive Aphasia: A Telepractice-Based Single-Case Study.

Brain sciences·2026

See all related articles

This summary is machine-generated.

Modified Music-Integrated Desynchronization Sound Therapy (mMIDST) significantly reduced tinnitus severity over three months compared to a control. This music-embedded approach offers a promising, well-tolerated treatment for chronic tinnitus distress.

Area of Science:

Neuroscience
Auditory Neuroscience
Clinical Otolaryngology

Background:

Tinnitus is linked to maladaptive brain plasticity and neural synchronization.
Current desynchronization therapies face accessibility challenges due to long sessions and specialized formats.
A modified protocol (mMIDST) embeds therapeutic tones in music to enhance tolerability and engagement.

Purpose of the Study:

To evaluate the clinical effectiveness of modified Music-Integrated Desynchronization Sound Therapy (mMIDST) for chronic tinnitus.
To assess the impact of mMIDST on tinnitus severity and patient-reported distress.

Main Methods:

Prospective, randomized, controlled, single-blind pilot trial.
Adults with chronic tinnitus received either mMIDST or low-frequency stimulation (LFS) in music for 1 hour daily, 5 days/week.

Keywords:

coordinated reset desynchronization music-embedded therapy sound therapy tinnitus

More Related Videos

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

Related Experiment Videos

Last Updated: Jun 27, 2026

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

A Protocol for the Administration of Real-Time fMRI Neurofeedback Training

Published on: August 24, 2017

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

Tinnitus Handicap Inventory (THI) and audiometry assessed outcomes at baseline and 1, 2, 3 months.

Main Results:

25 participants completed the study (15 mMIDST, 10 LFS) with comparable baseline characteristics.
The mMIDST group demonstrated significantly greater reductions in THI scores at 2 and 3 months versus LFS (p < 0.05).

Conclusions:

mMIDST showed time-dependent improvements in tinnitus-related distress compared to an active control.
Embedding desynchronization therapy in music is a potentially effective and well-tolerated non-invasive strategy for chronic tinnitus.