Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biosynthesis of Lipids

Biosynthesis of Lipids

Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis pathway, which...

Lipids as Anchors

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...

Lipid-derived Compounds in the Human Body

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Esters to Carboxylic Acids: Saponification

Esters to Carboxylic Acids: Saponification

Esters can be hydrolyzed to carboxylic acids under acidic or basic conditions. Base-promoted hydrolysis of esters is a nucleophilic acyl substitution reaction in which esters react with an aqueous base, followed by an acid to give carboxylic acids. This reaction is also known as saponification because it forms the basis for making soaps from fats.
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...

Formation of Lipopolysaccharides

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dynamic Prediction of 3-Month Recurrence After First-Ever Ischemic Stroke Using a Two-Stream Attention-LSTM Model - Henan Province, China, 2025.

China CDC weekly·2026

Same author

Development and external validation of an interpretable machine learning model for early prediction of stroke-associated pneumonia: a multicenter study.

International journal of medical informatics·2026

Same author

Daucane-type sesquiterpenes from Ferula sinkiangensis and their cytotoxic activities.

Fitoterapia·2026

Same author

Metabolomics coupled with machine learning highlights metabolite profile differences of Scutellaria baicalensis Georgi from different specifications and geographical origins.

Talanta·2026

Same author

Impact of PDCA cycle optimization on door-to-wire time in patients with acute st-segment elevation myocardial infarction: a single-center retrospective before-and-after QI study.

Heart & lung : the journal of critical care·2026

Same author

A multi-dimensional computational screening strategy for rapid identification of active components from traditional chinese medicine: Validation and application in Liangdi decoction against endometriosis.

Computational biology and chemistry·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

New lanostane-type triterpene acids from wolfiporia extensa.

Gaimei She¹, Nailiang Zhu, Shuai Wang

¹School of Chinese Pharmacy, Beijing University of Chinese Medicine, No, 6, Zhonghuan South Road, Wangjing District, Beijing, 100102, People's Republic of China. shirb@126.com.

Chemistry Central Journal

|May 8, 2012

Summary

Three novel lanostane triterpene acids were identified in Wolfiporia extensa sclerotia, a traditional Chinese medicine. This research expands our understanding of the chemical compounds found in this important medicinal fungus.

More Related Videos

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

Extraction of Plant-based Capsules for Microencapsulation Applications

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Related Experiment Videos

Last Updated: May 22, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

Extraction of Plant-based Capsules for Microencapsulation Applications

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Area of Science:

Natural Product Chemistry
Phytochemistry
Medicinal Mycology

Background:

Wolfiporia extensa sclerotia are utilized in traditional Chinese medicine for spleen invigoration and calming effects.
Lanostane-type triterpene acids are considered key secondary metabolites in W. extensa.

Purpose of the Study:

To isolate and characterize novel lanostane-type triterpene acids from W. extensa sclerotia.
To contribute to the phytochemical understanding of W. extensa.

Main Methods:

Isolation of compounds from W. extensa sclerotia.
Structure elucidation using spectroscopic analysis, including 1D and 2D-NMR techniques.

Main Results:

Three new lanostane-type triterpene acids: 3-epi-benzoyloxyl-dehydrotumulosic acid (1), 3-epi-(3'-O-methyl malonyloxy)-dehydrotumulosic acid (2), and 3-epi-(3'-hydroxy-3'-methylglutaryloxyl)-dehydrotumulosic acid (3).
Three known lanostane derivatives (4-6) were also isolated.
Structural confirmation through comprehensive spectroscopic analysis.

Conclusions:

Six lanostane derivatives, including three new triterpene acids, were identified from W. extensa sclerotia.
This study expands the known chemical constituents of W. extensa.