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Related Concept Videos

Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F). Physiological...
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

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Cell Signaling Feedback Loops01:07

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Diversity in Cell Signaling Responses01:22

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Related Experiment Video

Updated: May 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Beyond homeostasis: a predictive-dynamic framework for understanding cellular behavior.

Lydia Freddolino1, Saeed Tavazoie

  • 1Joint Centers for Systems Biology, Columbia University, New York, New York 10032, USA. petefred@c2b2.columbia.edu

Annual Review of Cell and Developmental Biology
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

Microbial cells use predictive strategies beyond simple homeostasis to respond to environmental changes. This predictive-dynamic framework explains how microbes anticipate future conditions based on habitat structure.

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The Use of Chemostats in Microbial Systems Biology
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The Use of Chemostats in Microbial Systems Biology

Published on: October 14, 2013

Related Experiment Videos

Last Updated: May 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

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The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 14, 2013

Area of Science:

  • Microbiology
  • Systems Biology
  • Evolutionary Biology

Background:

  • Microbial regulation traditionally viewed through a homeostatic lens, focusing on restoring internal balance.
  • This framework interprets cellular responses as reactions to immediate environmental impacts.

Purpose of the Study:

  • To review recent discoveries of microbial behaviors that extend beyond the homeostatic model.
  • To propose a predictive-dynamic framework for understanding microbial regulatory strategies.
  • To explore the evolutionary basis of predictive cellular behaviors.

Main Methods:

  • Literature review of recent research on microbial cellular behavior.
  • Analysis of environmental structures and their influence on microbial perception.
  • Synthesis of findings to support a new theoretical framework.

Main Results:

  • Microbial habitats possess multidimensional, nonrandom structures with temporal regularities.
  • These regularities enable microbes to predict environmental changes, not just react to them.
  • Examples of predictive behaviors and their physiological benefits are presented.

Conclusions:

  • Microbial regulation can be better understood through a predictive-dynamic framework.
  • Cellular behavior is shaped by the predictive meaning of environmental perturbations.
  • This perspective moves beyond homeostasis to encompass anticipatory microbial strategies.