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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Corneal transplantation.

Donald T H Tan1, John K G Dart, Edward J Holland

  • 1Singapore National Eye Centre, Singapore. snecdt@pacific.net.sg

Lancet (London, England)
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

Corneal transplantation has advanced significantly, with lamellar keratoplasty replacing penetrating keratoplasty for many conditions. These innovations improve outcomes for corneal blindness.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine

Background:

  • Corneal transplantation, or keratoplasty, has seen rapid advancements over the last decade.
  • Penetrating keratoplasty (PKP) was the standard for over 50 years, treating most corneal blindness.
  • Recent shifts favor lamellar keratoplasty techniques, selectively replacing diseased corneal layers.

Purpose of the Study:

  • To review recent advancements in corneal transplantation techniques.
  • To highlight the transition from penetrating to lamellar keratoplasty.
  • To discuss emerging therapies and future directions in treating corneal blindness.

Main Methods:

  • Review of recent literature on corneal transplantation techniques.
  • Comparison of penetrating keratoplasty with newer lamellar keratoplasty procedures.
  • Inclusion of emerging therapies like ocular surface reconstruction and keratoprosthesis.

Main Results:

  • Deep anterior lamellar keratoplasty (DALK) is increasingly used for stromal disorders, avoiding endothelial rejection.
  • Endothelial keratoplasty (EK) offers faster, more predictable visual recovery for endothelial diseases.
  • Ocular surface reconstruction and artificial cornea surgery are becoming more accessible.

Conclusions:

  • Modern corneal transplantation techniques, including lamellar procedures, offer improved outcomes.
  • These advances expand treatment options for previously untreatable corneal blindness.
  • Future developments include femtosecond laser use, bioengineered corneas, and medical treatments.