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Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Hormones and Bone Tissue

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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Skeleton and Calcium Homeostasis

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Related Experiment Video

Updated: May 22, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

Blocking FSH action attenuates osteoclastogenesis.

Ling-Ling Zhu¹, Irina Tourkova, Tony Yuen

¹School of Stomatology, Wuhan University, Wuhan, China.

Biochemical and Biophysical Research Communications

|May 8, 2012

Summary

This summary is machine-generated.

Follicle-stimulating hormone (FSH) directly impacts bone turnover by stimulating osteoclast formation. This study confirms FSH receptor (FSHR) expression in osteoclasts, revealing a specific isoform involved in this process.

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Area of Science:

Endocrinology
Bone Biology
Cell Biology

Background:

Follicle-stimulating hormone (FSH) has been implicated in bone turnover through osteoclast formation.
The precise mechanism and receptor involvement in osteoclasts remain under investigation.

Purpose of the Study:

To investigate the direct role of FSH and its receptor (FSHR) in osteoclast formation and function.
To identify and characterize the expression of FSHR in human osteoclast precursors and mature osteoclasts.

Main Methods:

Utilized monoclonal and polyclonal antibodies against FSH to inhibit FSH-induced osteoclast formation.
Generated FSH receptor (FSHR) knockout cells for comparative analysis.
Amplified FSHR cDNA from human CD14+ osteoclast precursors and osteoclasts.
Performed direct sequencing of PCR products to confirm FSHR expression and identify isoforms.

Main Results:

Antibodies targeting FSH significantly inhibited FSH-induced osteoclast formation, comparable to FSHR knockout cells.
Confirmed the expression of FSHR cDNA in human osteoclast precursors and osteoclasts.
Identified a predominant FSHR isoform lacking exon 9 in these cells, suggesting a distinct signaling pathway.

Conclusions:

These findings provide strong evidence for the expression of a specific FSH receptor isoform in osteoclasts and their precursors.
This supports a direct role for FSH signaling in regulating bone turnover via osteoclast modulation.