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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lemierre syndrome.

William F Wright1, Christine N Shiner, Julie A Ribes

  • 1From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. wwright@ihv.umaryland.edu

Southern Medical Journal
|May 8, 2012
PubMed
Summary
This summary is machine-generated.

Lemierre's syndrome, a rare complication of pharyngitis caused by Fusobacterium necrophorum, involves internal jugular vein thrombosis and lung abscesses. Early recognition and updated management strategies are crucial for effective treatment of this confusing infection.

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Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Bacteriology

Background:

  • Lemierre's syndrome is an uncommon but serious complication of pharyngitis.
  • It is most frequently caused by the bacterium Fusobacterium necrophorum.
  • The syndrome presents with internal jugular vein thrombosis and metastatic pulmonary abscesses.

Purpose of the Study:

  • To provide an updated review of Lemierre's syndrome.
  • To discuss current controversies in diagnosis and management.
  • To offer treatment recommendations for optimal patient care.

Main Methods:

  • Literature review of Lemierre's syndrome.
  • Analysis of diagnostic criteria and treatment options.
  • Examination of antimicrobial and anticoagulation therapy.

Main Results:

  • Fusobacterium necrophorum is the primary causative agent.
  • Internal jugular vein thrombosis and pulmonary abscesses are hallmark features.
  • Controversies exist regarding optimal antimicrobial and anticoagulation therapy duration.

Conclusions:

  • Practitioners must be familiar with Lemierre's syndrome signs, symptoms, diagnosis, and treatment.
  • Updated literature review and recommendations are needed for optimal management.
  • This often unrecognized infection requires prompt and informed medical attention.