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Updated: May 22, 2026

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
Published on: September 23, 2014
King of hearts: a splicing factor rules cardiac proteins
Wolfgang A Linke1, Sandra Bücker
1Department of Cardiovascular Physiology, Ruhr University Bochum, Germany. wolfgang.linke@rub.de
Abstract:
Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766-773).
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