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DNA polymerase beta (pol β) inhibitors: a comprehensive overview

Khaled H Barakat1, Melissa M Gajewski, Jack A Tuszynski

  • 1Department of Physics, University of Alberta, Edmonton, AB, Canada. kbarakat@ualberta.ca

Drug Discovery Today
|May 8, 2012
PubMed
Summary

Base excision repair (BER) eliminates damaged DNA bases. DNA polymerase beta (pol β) is crucial for BER but current inhibitors lack potency and specificity for drug development.

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