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Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices
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Application of Automated Image-guided Patch Clamp for the Study of Neurons in Brain Slices

Published on: July 31, 2017

Automated whole-cell patch-clamp electrophysiology of neurons in vivo

Suhasa B Kodandaramaiah1, Giovanni Talei Franzesi, Brian Y Chow

  • 1Media Lab, Massachusetts Institute of Technology, Cambridge, USA.

Nature Methods
|May 8, 2012
PubMed

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Related Concept Videos

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...