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A Fully Endovascular Neural Interface
Biorxiv : the Preprint Server for Biology
|June 22, 2026
Summary
Researchers developed a tiny, implantable device for endovascular neural stimulation. This ultrasound-powered neural interface can modulate autonomic functions, like blood pressure, offering a less invasive therapeutic approach.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Medical Devices
Background:
- Electrical stimulation of neural circuits is a growing therapeutic strategy.
- Endovascular devices offer a less invasive alternative to conventional implanted electrodes.
- Existing techniques lack spatio-temporal specificity compared to invasive methods.
Purpose of the Study:
- To demonstrate a fully endovascular, wireless neural implant.
- To utilize ultrasound for power and data transmission, independent of device orientation.
- To establish a platform for neural interfaces enabling stimulation and recording.
Main Methods:
- Developed a sub-1-mm3 implant with piezoelectric transducers, capacitor, integrated circuit, and electrodes on a polyimide scaffold.
- Delivered the implant via microcatheter, analogous to neurovascular stents.
- Demonstrated intravascular stimulation of the autonomic nervous system in rabbits via carotid artery access.
Main Results:
- Achieved wireless power delivery and data telemetry using ultrasound, invariant to device orientation.
- Successfully modulated blood pressure in rabbits through intravascular stimulation of the autonomic nervous system.
- The implant self-expands to appose vessel walls upon deployment.
Conclusions:
- This endovascular implant represents a broadly applicable platform for neural interfaces.
- The technology enables less invasive modulation of brain, autonomic, and immune functions.
- Offers improved spatio-temporal specificity over noninvasive techniques.
