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Published on: December 9, 2022
Risk factors for delayed recanalization of calf vein thrombosis
Yang Jin Park1, Kyung-Bok Lee, Dong-Ik Kim
1Division of Vascular Surgery, Department of Surgery, Cardiac and Vascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Insights
Oral anticoagulation therapy significantly improves recanalization rates in calf vein thrombosis (CVT). Immobilization and malignancy are key risk factors for delayed recanalization in CVT patients.
Area of Science:
- Vascular Medicine
- Thrombosis Research
- Medical Diagnostics
Background:
- Isolated calf vein thrombosis (CVT) is a common vascular condition.
- Understanding risk factors for delayed recanalization is crucial for effective patient management.
Purpose of the Study:
- To identify risk factors associated with delayed recanalization in patients diagnosed with isolated calf vein thrombosis (CVT).
Main Methods:
- A cohort of 110 patients with CVT was studied using ultrasonography for diagnosis and follow-up.
- Recanalization rates were assessed at 1 and 3 months post-diagnosis.
- Statistical analysis was performed to identify independent risk factors for delayed recanalization.
Main Results:
- Oral anticoagulation therapy was associated with significantly higher recanalization rates (84% vs. 65%).
- Malignancy (OR, 2.789) and immobilization (OR, 4.191) were identified as independent risk factors for delayed recanalization.
- Oral anticoagulation was an independent factor promoting recanalization (OR, 0.300).
Conclusions:
- Patients with isolated CVT treated without oral anticoagulation experienced higher rates of delayed recanalization.
- Immobilization and malignancy are significant independent risk factors contributing to delayed CVT recanalization.
Purpose:
To determine the risk factors of delayed recanalization of isolated calf vein thrombosis (CVT).
Methods:
One hundred fifty limbs of 110 patients with CVT between September 2007 and April 2010 were enrolled. We used ultrasonography for the diagnosis and follow-up examinations of CVT. We calculated recanalization rates at 1 and 3 months after initial diagnosis and analyzed the risk factors associated with delayed recanalization of CVT.
Results:
CVTs were located in the muscular calf vein in 110 (73.3%), in the deep calf vein in 18 (12%), and in both in 22 cases (14.7%). Among all CVTs, 94 limbs (63%) were symptomatic. Major risk factors for CVT were orthopedic surgery (87.3%), malignancy (21.3%), and immobilization (15.3%). Sixty-seven patients (60.9%) were treated with oral anticoagulation therapy, while 43 patients by low molecular weight heparin (n = 19) or by conservative methods including elastic compression stockings and ambulation (n = 21). The cumulative recanalization rate at 1 and 3 months was 23% and 82% and it was significantly higher in patients who underwent oral anticoagulation therapy compared with patients without oral anticoagulation therapy (84% vs. 65%, P = 0.008 by log-rank test). Malignancy (odds ratio [OR], 2.789; P = 0.043) and immobilization (OR, 4.191; P = 0.029) were independent risk factors for delayed recanalization of CVT and oral anticoagulation (OR, 0.300; P = 0.020) was an independent factor in promoting recanalization in multivariate analysis.
Conclusion:
For patients with isolated CVT, no oral anticoagulation resulted in higher rates of delayed recanalization compared to oral anticoagulation treatment. Immobilization and having malignancy were independent risk factors for delayed recanalization.
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