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Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Related Experiment Video

Updated: May 22, 2026

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
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Published on: March 29, 2018

Gestational pemphigoid: placental morphology and function.

Laura Huilaja1, Kaarin Mäkikallio, Raija Sormunen

  • 1Deparment of Dermatology and Oulu Center for Cell-Matrix Research, University of Oulu, Oulu University Hospital, Oulu, Finland.

Acta Dermato-Venereologica
|May 9, 2012
PubMed
Summary

Gestational pemphigoid (PG) in pregnancy can affect placental structure, showing minor basement membrane changes. However, placental function typically remains normal, with generally good neonatal outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Dermatology
  • Immunology

Background:

  • Gestational pemphigoid (PG) is a rare pregnancy dermatosis linked to adverse outcomes.
  • Autoantibodies in PG target collagen XVII (BP180), potentially causing placental issues.

Purpose of the Study:

  • To evaluate clinical outcomes and placental morphology/function in pregnancies with gestational pemphigoid.

Main Methods:

  • Analysis of 12 PG pregnancies (2002-2011) including clinical data, placental weight ratios, ultrastructural analysis, and ultrasound.
  • Umbilical artery Doppler used for placental function assessment.

Main Results:

  • Half of pregnancies showed abnormal placental-to-birth weight ratio.
  • Ultrastructural analysis revealed placental basement membrane detachment and undeveloped hemidesmosomes.
  • Placental function via ultrasound was normal in most cases; 25% neonates were preterm.

Conclusions:

  • Gestational pemphigoid pregnancies exhibit subtle ultrastructural placental basement membrane alterations.
  • Umbilical artery Doppler indicated no significant functional placental impairment in PG pregnancies.