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Related Experiment Video

Updated: May 22, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

The human cutaneous chemokine system.

Michelle L McCully¹, Bernhard Moser

¹Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University Cardiff, UK.

Frontiers in Immunology

|May 9, 2012

Summary

This summary is machine-generated.

Most T cells reside in tissues, not blood. This study explores how memory T cells migrate to skin, proposing CCR8 and CCL1 regulate this crucial immune surveillance process.

Keywords:

Human chemokines homing immune surveillance memory T cells skin

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Quantifying Human Monocyte Chemotaxis In Vitro and Murine Lymphocyte Trafficking In Vivo

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Published on: October 30, 2017

Area of Science:

Immunology
Cell Biology

Background:

The majority of lymphocytes, including T cells, are found in peripheral tissues, not circulating blood.
Understanding the relationship and function of T cells in blood versus tissues is crucial for immune surveillance.

Purpose of the Study:

To review T cell homing mechanisms to human skin.
To compare skin-homing with gut-selective homing.
To propose a model for the regulation of T cell localization in skin.

Main Methods:

Literature review of T cell homing and chemokine functions.
Comparative analysis of T cell distribution in skin and blood.
Discussion of candidate chemokines involved in tissue-specific homing.

Main Results:

T cells in healthy human skin significantly outnumber those in blood.
Peripheral blood T cell subsets may not accurately represent tissue-resident T cell function.
CCR8 and its ligand CCL1 are proposed as key regulators of memory T cell homing to skin.

Conclusions:

The study highlights the importance of tissue-resident T cells for immune surveillance.
A model is presented where CCR8/CCL1 mediate selective homing of memory T cells to skin.
Further research into chemokine-mediated T cell trafficking is warranted for understanding tissue immunity.