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[Gastric acid secretion in children with duodenal ulcer]
1Unité de Gastroentérologie et de Nutrition Pédiatriques, Hôpital E.-Herriot, Lyon.
Insights
Pediatric duodenal ulcer patients exhibit similar gastric acid secretion levels to adults. Chronic ulcers in children do not correlate with increased acid output, but family history does.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Physiology
Background:
- Duodenal ulcers are increasingly diagnosed in children.
- Understanding gastric acid secretion in pediatric duodenal ulcer disease is crucial for effective management.
Purpose of the Study:
- To compare gastric acid secretion in children with primary duodenal ulcers to adults with duodenal ulcers.
- To investigate the relationship between ulcer chronicity, family history, and gastric acid secretion in children.
Main Methods:
- Measured basal acid output (BAO) and peak acid output (PAO) under pentagastrin stimulation in 17 children with duodenal ulcers.
- Compared pediatric data to historical data from 32 adults with duodenal ulcers.
- Analyzed differences based on ulcer chronicity and presence of affected first-degree relatives.
Main Results:
- Gastric acid secretion (BAO and PAO) in children was comparable to adults with duodenal ulcers.
- No significant difference in BAO or PAO was observed between children with chronic or non-chronic ulcers.
- Children with a first-degree relative affected by ulcers showed significantly higher BAO and PAO (p < 0.05).
Conclusions:
- Gastric acid secretion levels in pediatric and adult duodenal ulcer patients are similar.
- Ulcer chronicity in childhood does not appear to be linked to elevated gastric acid secretion.
- A positive family history of duodenal ulcers may indicate a predisposition to higher gastric acid secretion in children.
Abstract:
Gastric acid secretion was studied in 17 children with primary duodenal ulcer (mean age: 10 yrs 4 mo, rang: 4-16). Eight of the 17 children with primary ulcer had chronic evolution and 10 of them had an affected first degree relative. Basal acid output (BAO) and peak acid output under pentagastrin (PAO) were not significantly different in the 17 children (0.094 +/- 0.085 mmol/kg/hr; 0.483 +/- 0.235 mmol/kg/hr) and in 32 adults with duodenal ulcer (0.073 +/- 0.010 mmol/kg/hr; 0.477 +/- 0.021 mmol/kg/hr). BAO and PAO were not significantly different between children with or without chronic ulcer. The BAO and PAO of children with an affected first degree relative were significantly higher than those of children without (p less than 0.05). This study shows that gastric acid secretions are similar in children and adults with duodenal ulcer. The chronicity of duodenal ulcer in childhood is not associated with increased acid secretion. Gastric acid secretion seems to be higher in children with an affected first degree relative than those without.