Related Experiment Video

Updated: Dec 30, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

3.3K

Multifocal arterial wall contrast - enhancement in ischemic stroke: A mirror of systemic inflammatory response in

R Ameli1, O Eker2, M Sigovan3

  • 1Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.

Revue Neurologique
|January 29, 2020
PubMed
Abstract

Insights

Gadolinium enhancement in intracranial plaques, detected by high-resolution MRI (HR MRI), is common in stroke patients. This enhancement may indicate a widespread inflammatory process affecting both culprit and asymptomatic plaques.

Area of Science:

  • Neurology
  • Radiology
  • Cardiovascular Science

Background:

  • Intracranial plaque gadolinium enhancement on high-resolution MRI (HR MRI) signifies plaque inflammation.
  • Plaque inflammation is a key factor in the instability of atherosclerotic plaques.
  • Understanding gadolinium enhancement patterns is crucial for assessing stroke risk.

Purpose of the Study:

  • To evaluate the distribution of gadolinium enhancement in intracranial atherosclerotic plaques.
  • To investigate the association between gadolinium enhancement and plaque characteristics in stroke patients.

Main Methods:

  • Analysis of ischemic stroke patients with middle cerebral artery or internal carotid artery stenosis.
  • High-resolution MRI (HRMRI) including 3DT2 BB and 3D T1 BB sequences pre- and post-contrast.
  • Identification and characterization of intracranial plaques.

Main Results:

  • 14 plaques were analyzed in 8 patients; 10 were culprit plaques and 4 were non-culprit.
  • All 10 culprit plaques demonstrated gadolinium enhancement.
  • 3 of the 4 non-culprit plaques also showed gadolinium enhancement.

Conclusions:

  • Gadolinium enhancement can be present in multiple intracranial plaques, including asymptomatic ones, during the acute/subacute stroke phase.
  • The findings suggest that gadolinium enhancement may reflect a systemic inflammatory state in patients with intracranial atherosclerosis.
  • This highlights the potential of HR MRI in identifying inflammatory activity beyond the index lesion.
Keywords:
Atherosclerotic plaqueHigh-resolution vessel wall MRIMRIStroke

More Related Videos

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

49.2K
Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli13:10

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

10.2K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
271
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
155