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Updated: May 22, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Factors determining changes in initial antiretroviral therapy.

Denise Girão Limaverde Lima¹, Érico Antonio Gomes de Arruda, Antonio Jorge Alves de Lima

¹Public Health School of Ceará (ESP-CE), Brazil. deniseglvl@yahoo.com.br

Revista Da Associacao Medica Brasileira (1992)

|May 10, 2012

Summary

Adverse reactions were the primary reason for changing initial antiretroviral therapy (ART) in Brazilian patients within the first year. Most patients required only one ART regimen adjustment, highlighting the importance of monitoring drug therapy.

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Area of Science:

Infectious Diseases
Pharmacology
Public Health

Background:

Antiretroviral therapy (ART) is crucial for managing HIV/AIDS.
Understanding factors influencing initial ART changes is vital for optimizing patient outcomes.
Tertiary care centers play a key role in managing complex HIV cases.

Purpose of the Study:

To identify factors influencing changes in initial antiretroviral therapy (ART).
To analyze the frequency and reasons for ART modifications in the first year of treatment.
To assess the impact of ART monitoring on treatment control.

Main Methods:

Descriptive and exploratory study analyzing treatment initiation and change forms from 2008.
Follow-up of therapy changes during the first year of treatment.
Statistical analysis using ANOVA and exact test of the coefficient of contingency (p < 0.05).

Main Results:

22.1% of 301 patients initiating ART required a change within the first year.
Adverse reactions were significantly associated with initial ART regimen changes (p < 0.001).
Zidovudine, lopinavir/ritonavir, and efavirenz were the most frequently changed drugs.

Conclusions:

Adverse reactions are the main determinant for initial ART modifications.
The majority of patients experienced one ART change in the first year.
ART monitoring aids in achieving better control of specific drug therapies.