Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

QSM Measurement of Iron Deposition in the Substantia Nigra and Its Relationship to Brain Functional Connectivity in Patients with Early Stage and Advanced Stage Parkinson's Disease.

Current neuropharmacology·2026
Same author

T<sub>1</sub> Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions.

Annals of clinical and translational neurology·2026
Same author

Progressive iron deposition and widespread neural dysfunction in Parkinson's disease: a multimodal MRI study.

Quantitative imaging in medicine and surgery·2026
Same author

An Integrated QSM-Radiomics Nomogram With Clinical and Imaging Markers for Stratifying Cognitive Impairment in Hypertension.

CNS neuroscience & therapeutics·2026
Same author

Clinical Validation of a Fast MRI Method to Evaluate Brain Vascular and Parenchymal Abnormalities in Sturge-Weber Syndrome.

Journal of magnetic resonance imaging : JMRI·2025
Same author

Partial volume correction for quantifying venous oxygen saturation levels using contrast-enhanced MRI.

NeuroImage·2025

Related Experiment Video

Updated: May 22, 2026

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

Quantitative susceptibility mapping of small objects using volume constraints.

Saifeng Liu1, Jaladhar Neelavalli, Yu-Chung N Cheng

  • 1School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.

Magnetic Resonance in Medicine
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

Magnetic susceptibility offers a new way to measure microbleeds, crucial in neurodegenerative diseases. Accurate quantification of these small brain bleeds requires knowing their volume, suggesting magnetic moment may be a better metric.

More Related Videos

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy
09:47

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

Quantitative Optical Microscopy: Measurement of Cellular Biophysical Features with a Standard Optical Microscope
14:09

Quantitative Optical Microscopy: Measurement of Cellular Biophysical Features with a Standard Optical Microscope

Published on: April 7, 2014

Related Experiment Videos

Last Updated: May 22, 2026

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images
12:45

Detection and Quantification of Tunneling Nanotubes Using 3D Volume View Images

Published on: August 31, 2022

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy
09:47

Array Tomography Workflow for the Targeted Acquisition of Volume Information using Scanning Electron Microscopy

Published on: July 15, 2021

Quantitative Optical Microscopy: Measurement of Cellular Biophysical Features with a Standard Optical Microscope
14:09

Quantitative Optical Microscopy: Measurement of Cellular Biophysical Features with a Standard Optical Microscope

Published on: April 7, 2014

Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Microbleeds are linked to neurovascular and neurodegenerative diseases.
  • Current grading of microbleeds relies on diameter, a limited quantitative measure.
  • Magnetic susceptibility is proposed as a novel quantitative measure for extravasated blood.

Purpose of the Study:

  • To evaluate the accuracy of a Fourier-based susceptibility mapping method for small objects like microbleeds.
  • To assess the impact of object size on susceptibility quantification accuracy.
  • To explore alternative quantitative measures for microbleeds.

Main Methods:

  • Utilized air bubbles and glass beads as surrogates for microbleeds.
  • Employed a Fourier-based method for susceptibility quantification from phase images.
  • Evaluated remnant errors and their sources in quantified susceptibilities.

Main Results:

  • Accurate susceptibility quantification of microbleed-sized objects requires an estimate of their true volume.
  • The accuracy of the susceptibility mapping method is limited for objects occupying only a few voxels.
  • Quantifying magnetic moment is identified as a more robust alternative to susceptibility for small structures.

Conclusions:

  • The Fourier-based susceptibility mapping method needs volume estimation for accurate quantification of small structures.
  • Magnetic moment offers a potentially more reliable quantitative measure for microbleeds compared to susceptibility.
  • Further research is needed to refine methods for accurate microbleed quantification in neuroimaging.