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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: May 22, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Posttransplant lymphoproliferative disorders.

Hazem A H Ibrahim1, Kikkeri N Naresh

  • 1Department of Histopathology, Hammersmith Hospital Campus, Imperial College Healthcare NHS Trust and Imperial College, London W12 0HS, UK.

Advances in Hematology
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

Posttransplant lymphoproliferative disorders (PTLDs) result from immunosuppression after organ transplant. PTLDs involve Epstein-Barr virus (EBV), genetic changes, and immune cell roles in their complex development.

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Last Updated: May 22, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

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Published on: May 2, 2013

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
12:58

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

Published on: May 10, 2017

Area of Science:

  • Immunology
  • Oncology
  • Transplantation Medicine

Background:

  • Posttransplant lymphoproliferative disorders (PTLDs) are lymphoid proliferations following immunosuppression for organ transplant.
  • PTLDs exist on a spectrum from benign to malignant, with distinct early, polymorphic, and monomorphic stages.
  • Immunosuppressive therapy is crucial for preventing transplant rejection but can predispose patients to PTLDs.

Purpose of the Study:

  • To elucidate the multifactorial pathogenesis of posttransplant lymphoproliferative disorders (PTLDs).
  • To explore the roles of Epstein-Barr virus (EBV), genetic alterations, and immune cells in PTLD development.
  • To understand the interplay of viral, genetic, and immunological factors in PTLD pathogenesis.

Main Methods:

  • Review of existing literature on PTLD pathogenesis.
  • Analysis of the role of Epstein-Barr virus (EBV) in B-cell proliferation.
  • Investigation of genetic alterations (oncogenes, tumor suppressor genes) and epigenetic changes.
  • Examination of the involvement of plasmacytoid dendritic cells (PDCs) and regulatory T cells (Treg cells).

Main Results:

  • Epstein-Barr virus (EBV) is a key factor, driving proliferation of infected B cells.
  • Accumulated genetic alterations, including mutations and epigenetic changes, are integral to PTLD development.
  • Antigenic stimulation, involving PDCs and Treg cells, plays a significant role in PTLD pathogenesis.

Conclusions:

  • PTLD pathogenesis is complex, involving viral (EBV), genetic, and immunological factors.
  • EBV initiates B-cell proliferation, but genetic alterations are necessary for malignant transformation.
  • Immune cells like PDCs and Treg cells modulate the immune response and contribute to PTLD development, especially under antigenic stimulation.