Related Experiment Video
Updated: May 22, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Thyrotropin as an independent factor of renal function and chronic kidney disease in normoglycemic euthyroid adults
Ming-Tsung Sun1, Fone-Ching Hsiao, Sheng-Chiang Su
1Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan, PR China.
Objectives:
The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between thyroid and renal function in large population of normoglycemic euthyroid adults.
Design:
Population-based cross-sectional survey.
Patients:
A total of 8,418 normoglycemic euthyroid participants were recruited after excluding individuals with thyroid dysfunction (thyrotropin, TSH < 0.47 mU/L, TSH ≥ 5.0 mU/L) or dysglycemia (fasting glucose ≥100 mg/dL).
Measurements:
Anthropometric measurements were collected, and creatinine, TSH, and fasting glucose levels were evaluated. Renal function was determined by the estimated glomerular filtration rate (e-GFR) calculated using the simplified Modification of Diet in Renal Disease formula.
Results:
TSH levels were inversely correlated with e-GFR. After adjustment for confounding factors, multivariate analysis revealed that TSH remained an independent factor of e-GFR in both genders (beta = -1.512 in males and -1.685 in females), and TSH was an independent factor of chronic kidney disease (OR = 1.28, 95% CI = 1.021-1.604).
Conclusions:
TSH is an independent factor for determining renal function and chronic kidney disease in normoglycemic euthyroid adults.
Related Concept Videos
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Serum Studies: Renal Function Tests
Chronic Kidney Disease III: Interprofessional Care
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Hypothyroidism II: Pathophysiology
