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Use of live Saccharomyces cerevisiae cells as a biological response modifier in experimental infections
1Laboratory of Toxin Immunochemistry, Pasteur Institute, Paris, France.
Abstract:
A short-term oral administration of live Saccharomyces cerevisiae cells, strain Sillix Hansen DSM 1883, resulted in enhanced resistance of mice toward infections with K. pneumoniae. S. pneumoniae and S. pyogenes A produced by intranasal inoculation. Yeast pre-treatment also increased the efficacy of antibiotic therapy in bacterial infections and of antiviral drugs in viral infections. Yeast treatment of animals stimulated phagocytosis, activated the complement system and induced interferon which are likely to represent the main mechanisms of action whereby pretreatment of mice with live S. cerevisiae cells increases resistance to infection. It is concluded that preventive administration of live Saccharomyces cerevisiae cells should be used for increasing resistance to bacterial infections, in particular of the respiratory tract, or to viral infections, as well as an adjunct to antibiotic and antiviral drug therapy.
Insights
Live Saccharomyces cerevisiae (yeast) oral administration boosted mice resistance to bacterial and viral infections. Yeast also enhanced antibiotic and antiviral drug efficacy, suggesting its use for infection prevention and treatment support.
Area of Science:
- Immunology
- Microbiology
- Pharmacology
Background:
- Infections pose significant health challenges.
- The need for effective prophylactic and therapeutic strategies is crucial.
- Saccharomyces cerevisiae is a well-known probiotic yeast.
Purpose of the Study:
- To investigate the impact of live Saccharomyces cerevisiae on host resistance to infections.
- To evaluate Saccharomyces cerevisiae as an adjunct therapy for antibiotic and antiviral treatments.
Main Methods:
- Oral administration of live Saccharomyces cerevisiae (strain Sillix Hansen DSM 1883) to mice.
- Challenging pre-treated mice with intranasal inoculations of Klebsiella pneumoniae, Streptococcus pneumoniae, and Streptococcus pyogenes.
- Assessing the efficacy of yeast pre-treatment in conjunction with antibiotic and antiviral therapies.
Main Results:
- Live Saccharomyces cerevisiae administration significantly enhanced resistance against K. pneumoniae, S. pneumoniae, and S. pyogenes infections.
- Yeast pre-treatment improved the effectiveness of both antibiotic and antiviral drug therapies.
- Mechanisms involved increased phagocytosis, complement system activation, and interferon induction.
Conclusions:
- Preventive oral administration of live Saccharomyces cerevisiae enhances host resistance to bacterial and viral infections, particularly respiratory tract infections.
- Live Saccharomyces cerevisiae serves as a valuable adjunct to conventional antibiotic and antiviral therapies.