Anti-ribosomal P antibody in schizophrenia

Area of Science:

• Neuroscience
• Immunology
• Psychiatry

Background:

• Growing evidence suggests autoimmune involvement in schizophrenia.
• Antiribosomal P antibodies are linked to psychosis in systemic lupus erythematosus (SLE).

Purpose of the Study:

• To determine if antiribosomal P antibodies are present in patients with schizophrenia.
• To assess the potential of antiribosomal P antibody as a biomarker for schizophrenia.

Main Methods:

• Enzyme-linked immunosorbent assay (ELISA) was used to detect antiribosomal P antibody titers.
• Sera from 59 schizophrenia/schizoaffective disorder patients and 94 healthy controls were analyzed.

Main Results:

• Anti-ribosomal P antibody titers were below cut-off in most patients, similar to controls.
• One patient had borderline titers, not significantly elevated.

Conclusions:

• Anti-ribosomal P antibody is not a specific biological marker for schizophrenia.
• Findings do not support a role for this antibody in schizophrenia pathogenesis.