Percutaneous coronary intervention in cardiogenic shock complicating acute ST-elevation myocardial infarction-a

Vijayakumar Subban1, Anand Gnanaraj, Balashankar Gomathi

  • 1Department of Cardiology, Madras Medical Mission, Tamilnadu, India.

Insights

Early revascularization improves survival in acute myocardial infarction (AMI) with cardiogenic shock (CS). Achieving TIMI 3 flow in the infarct-related artery is key for survival after percutaneous coronary intervention (PCI).

Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Mortality in acute myocardial infarction (AMI) with cardiogenic shock (CS) remains high (70-80%) despite pharmacological treatments.
  • Early revascularization is crucial for improving survival in AMI patients experiencing CS.

Purpose of the Study:

  • To assess predictors of mid-term outcomes in ST-segment elevation myocardial infarction (STEMI) patients with CS.
  • Evaluate survival rates after percutaneous coronary intervention (PCI) in STEMI with CS.

Main Methods:

  • Analysis of 41 patients undergoing primary or rescue PCI for CS.
  • Comparison of baseline, angiographic, and PCI data with 30-day and 1-year survival.

Main Results:

  • Higher rates of transfer admissions and cardiopulmonary resuscitations were observed in non-survivors.
  • Pre-procedure Thrombolysis In Myocardial Infarction (TIMI) flow grade 3 in the infarct-related artery (IRA) significantly correlated with better survival (P=0.0005).
  • Successful PCI was achieved in 48.8% of patients, with significantly better short-term survival compared to failed PCI (80% vs 9.6%). 30-day mortality was 56.1%.

Conclusions:

  • Mortality remains high in STEMI with CS, even after PCI.
  • Achieving IRA patency with TIMI 3 flow is the primary determinant of survival.
  • Patients discharged from the hospital after PCI demonstrate good survival and functional status.
Abstract

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...