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Updated: May 22, 2026

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

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[Iodine allergy].

A Weinstabl¹, P M Amann, G Wurpts

¹Klinik für Dermatologie und Allergologie, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Deutschland. aweinstabl@ukaachen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|May 11, 2012

Summary

This summary is machine-generated.

A patient experienced a delayed skin reaction to iodinated contrast media and povidone-iodine. Allergy testing confirmed sensitivity to iodine and related compounds, but not povidone itself.

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Published on: September 12, 2018

Area of Science:

Allergy and Immunology
Radiology
Dermatology

Background:

Iodinated radiographic contrast media (ICM) are essential for medical imaging.
Povidone-iodine (PVP-I) is a common topical antiseptic.
Iodine allergy is rare but can cause significant reactions.

Observation:

A patient presented with a delayed cutaneous reaction after receiving ICM and topical PVP-I.
The reaction manifested as a skin rash at the sites of exposure.
The patient had no prior known history of iodine sensitivity.

Findings:

Patch and intradermal testing revealed positive reactions to various ICM, PVP-I, and elemental iodine.
Importantly, the patient tested negative for povidone alone, indicating iodine as the causative agent.
This suggests a specific allergy to iodine rather than the entire PVP-I complex.

Implications:

This case highlights the importance of considering iodine as the primary allergen in patients reacting to ICM and PVP-I.
Accurate allergy testing is crucial for differentiating between iodine and povidone sensitivities.
Clinicians should be aware of potential cross-reactivity between different iodine-containing agents.