Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Visual Agnosia01:12

Visual Agnosia

Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round end"...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-Sectional and Longitudinal Patterns of Atrophy in Thalamic and Deep Gray Matter Nuclei in Frontotemporal Dementia.

medRxiv : the preprint server for health sciences·2025
Same author

Acute effect of a Mediterranean-style dietary pattern (MDP) on mood, anxiety and cognition in UK adults with mild to moderate anxiety and depression: the MediMood randomised controlled trial protocol.

BMJ open·2025
Same author

Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial.

BMC medicine·2024
Same author

No link between handedness and spatial navigation: evidence from over 400 000 participants in 41 countries.

Proceedings. Biological sciences·2023
Same author

Cultural determinants of the gap between self-estimated navigation ability and wayfinding performance: evidence from 46 countries.

Scientific reports·2023
Same author

Entropy and a sub-group of geometric measures of paths predict the navigability of an environment.

Cognition·2023
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Saccadic abnormalities in frontotemporal dementia.

J R Burrell1, M Hornberger, R H S Carpenter

  • 1Neuroscience Research Australia, Prince of Wales Clinical School Hospital, University of New South Wales, Sydney, Australia.

Neurology
|May 11, 2012
PubMed
Summary
This summary is machine-generated.

Saccadic eye movements in frontotemporal dementia (FTD) show reduced decision-making speed and increased early saccades, linked to frontal lobe atrophy. These findings highlight FTD

More Related Videos

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Related Experiment Videos

Last Updated: May 22, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Frontotemporal dementia (FTD) is a neurodegenerative disease affecting decision-making.
  • Saccadic eye movements serve as a potential biomarker for cognitive processes.

Purpose of the Study:

  • To investigate saccadic eye movements as indicators of decision-making deficits in FTD.
  • To correlate saccadic abnormalities with patterns of brain atrophy in FTD patients.

Main Methods:

  • Saccadometry was employed on FTD patients and matched controls.
  • The Linear Approach to Threshold with Ergodic Rate model quantified decision-making speed and early saccade incidence.
  • Voxel-based morphometry (VBM) analyzed the relationship between cortical atrophy and decision-making metrics.

Main Results:

  • FTD patients exhibited reduced decision-making speed (prolonged saccadic latency) and increased early saccades compared to controls.
  • Antisaccade task performance was impaired in FTD.
  • Decision-making speed and early saccade incidence correlated with atrophy in the left frontal eye field and cingulate eye field.

Conclusions:

  • Saccadic abnormalities, including slower decision-making and increased early saccades, are characteristic of FTD.
  • These saccadic changes are associated with atrophy in specific frontal brain regions.
  • Increased early saccades in FTD may result from impaired inhibitory control.