[Hypomagnesemia and proton pump inhibitors]

Area of Science:

• Biochemistry
• Physiology
• Pharmacology

Context:

• Magnesium (Mg2+) is a critical intracellular cation and cofactor for numerous enzymatic reactions.
• Maintaining serum Mg2+ homeostasis is vital for neurological, cardiac, and muscular functions.
• Serum Mg2+ balance relies on intestinal absorption and renal excretion.

Purpose:

• To highlight the rare occurrence of hypomagnesaemia associated with proton pump inhibitors (PPIs).
• To discuss the potential pathogenesis of PPI-induced hypomagnesaemia.
• To underscore the importance of monitoring magnesium levels during PPI therapy.

Summary:

• Hypomagnesaemia during proton pump inhibitors (PPIs) treatment is infrequently reported.
• The exact mechanism remains unclear but may involve reduced intestinal Mg2+ absorption.
• This highlights a potential adverse effect of long-term PPI use.

Impact:

• Raises awareness among clinicians regarding a potential adverse effect of PPIs.
• Suggests the need for monitoring magnesium levels in patients on long-term PPI therapy.
• Contributes to understanding drug-induced electrolyte imbalances.