Related Experiment Video
Updated: May 22, 2026

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
Published on: December 23, 2014
Mechanisms of endogenous endothelial repair in stroke
1Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan.
Abstract:
Recent evidence indicates that circulating endothelial progenitor cells can play an important role, not only in endothelium homeostasis of the pre-stroke brain, but also in angiogenesis of the post-stroke brain. Circulating endothelial progenitor cells are considered to repair endothelial cells by incorporating them into newly formed vessels, or by releasing pro-angiogenic factors. The number or function of circulating endothelial progenitor cells can be modulated by various kinds of factors. For example, elevated serum cholesterol, hypertension, diabetes and smoking decreased the number whereas vascular endothelial growth factor (VEGF), exercise, and statins can increase it. In this review, we discuss the present knowledge of endogenous mechanisms for the repair of endothelial cells, and how to enhance their possible capacity to remodel vascular units as neuronal self-repair strategies.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Mechanism of Angiogenesis
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Clot Retraction and Fibrinolysis
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Vascular Spasm
