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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
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Published on: March 13, 2013

CD147 expression in advanced cutaneous squamous cell carcinoma.

Larissa Sweeny1, Nichole R Dean, John W Frederick

  • 1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alabama at Birmingham, AL 35233, USA.

Journal of Cutaneous Pathology
|May 12, 2012
PubMed
Summary

CD147 is overexpressed in advanced cutaneous squamous cell carcinoma (SCC), potentially linking it to poorer survival. This suggests CD147 could be a therapeutic target for SCC patients.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Immunohistochemistry

Background:

  • CD147 is frequently upregulated in various cancers.
  • Its role in advanced cutaneous squamous cell carcinoma (SCC) remains largely uncharacterized.
  • Monocarboxylate transporters (MCT1, MCT4) are involved in cancer metabolism and may interact with CD147.

Purpose of the Study:

  • To investigate the expression patterns of CD147, MCT1, and MCT4 in advanced cutaneous SCC.
  • To determine the correlation between the expression of these markers and patient survival.
  • To explore the potential of CD147 as a biomarker or therapeutic target in this cancer type.

Main Methods:

  • Retrospective cohort study of 50 patients with advanced cutaneous SCC of the head and neck.
  • Immunofluorescence analysis of archived tumor samples to assess CD147, MCT1, and MCT4 expression.
  • Correlation of marker expression with survival and clinicopathologic characteristics, including lymph node metastasis.

Main Results:

  • Overexpression of CD147 was observed in 78% of primary tumors.
  • CD147 overexpression showed a significant association with positive regional lymph node metastasis (p=0.048).
  • Trends indicated decreased survival with overexpression of CD147, MCT1, and MCT4, though not statistically significant (p > 0.10).

Conclusions:

  • CD147 is frequently overexpressed in advanced cutaneous SCC.
  • CD147 expression is linked to adverse clinicopathologic features like lymph node metastasis.
  • CD147 warrants further investigation as a potential biomarker and therapeutic target for advanced cutaneous SCC.