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[Study on the relationship between iodine status and growth in infants at the key period of brain development]
Yan-ling Wang1, Peng-fei Ge, Qi-yi Ma
1Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China. wylxiao@126.com
Insights
Iodine deficiency in infants retards growth and brain development. Supplementing with iodized oil significantly improved infant development, height, and weight, highlighting the importance of adequate iodine nutrition.
Area of Science:
- Pediatric Nutrition
- Developmental Pediatrics
- Public Health Nutrition
Context:
- Iodine is crucial for infant brain development.
- Iodine deficiency disorders (IDDs) pose a significant public health challenge.
- Early life nutrition impacts long-term health outcomes.
Purpose:
- To assess the impact of iodized oil supplementation on infant growth and neurodevelopment.
- To evaluate urinary iodine levels in infants, pregnant, and lactating women following an intervention.
- To establish the relationship between iodine status and developmental milestones in early childhood.
Summary:
- A study in Linxia Prefecture involved iodized oil supplementation for pregnant women, lactating women, and infants from 2006-2010.
- Post-intervention, median urinary iodine (UI) levels increased significantly in all groups.
- Infant DQ scores, height, and weight showed statistically significant improvements (P < 0.05) compared to pre-intervention levels.
Impact:
- Adequate iodine intake is vital for optimal infant growth and neurodevelopment.
- Iodized oil supplementation effectively improved developmental outcomes in infants.
- This intervention strategy can mitigate the adverse effects of iodine deficiency during critical developmental periods.
Objective:
To investigate the relationship between iodine nutrition and growth/development in infants at the key period of brain development.
Methods:
All women from pregnancy to the end of lactation and the weaning infants within 3 years in the Linxia Hui Autonomous Prefecture (Linxia Prefecture) were added iodized oil in 2006 - 2010. In 2006, 2010 one town was randomly selected from each of the five directions (east, south, west, north, central) of each county in Linxia Prefecture. One village was chosen from every town and 20 infants, 20 pregnant women and 20 lactating women were randomly selected in each town. Urinary iodine (UI) of the infants, pregnant and lactating women were determined. DQ value, height and weight of part of infants were measured. According to the above sampling plan, UI of pregnant women, lactating women and infants had been monitored every year after intervention. 0-3 infants were choosing to be control before intervention.
Results:
UI of 1056 and 2989 0-3 infants were investigated before and after the iodine oil intervention. After the 'iodine oil' intervention, the median UI of infants increased from 107.3 µg/L to 139.6 - 190.7 µg/L, the percentage of UI level that lower than 50 µg/L, decreased from 23.9% to 6.7% - 12.9%. DQ value increased from 92.8 to 104.3, the percentage of normal height and above increased from 65.0% to 82.1% and the percentage of the normal weight and above, increased from 59.3% to 81.4%. The outcomes of DQ value, height and weight showed statistically significant differences, compared to the pre-intervention outcomes (P < 0.05). The median UI of pregnant and lactating women increased from 89.3 µg/L to 118.2 - 187.8 µg/L and from 84.9 µg/L to 135.2 - 187.5 µg/L respectively.
Conclusion:
Infant's growth and development were retarded when iodine deficiency existed at the key period of brain development. Intake of oral iodine oil at key period of brain development could provide adequate nutrition thus improve growth and development on infants.
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