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Vitamin E: supplement versus diet in neurodegenerative diseases
1Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo 255049, P.R. China. shen@sdut.edu.cn
Abstract:
Contradicting outcomes have been observed in numerous studies investigating the benefits of vitamin E supplements in the context of neurodegenerative diseases. By reviewing epidemiological studies and clinical trials, it is found that dietary intake of vitamin E exhibits beneficial effects on neurodegeneration, whereas α-tocopherol supplements failed in most interventional trials. Potential reasons for why α-tocopherol supplements exhibit disappointing effects, especially compared with dietary intake, are put forward and implications for future studies are discussed.
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