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To differentiate or not--routes towards metastasis

Thomas Brabletz1

  • 1Department of General and Visceral Surgery and Comprehensive Cancer Center, University of Freiburg Medical Center, Hugstetter Str. 55, 79106 Freiburg, Germany. thomas.brabletz@uniklinik-freiburg.de

Nature Reviews. Cancer
|May 12, 2012
PubMed
Summary

Metastatic cancer cells may remain differentiated or undergo epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). This study proposes two progression types: transient EMT-MET plasticity or sustained EMT and stemness for targeted cancer therapies.

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