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Updated: May 22, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
The role of the PGE2-aromatase pathway in obesity-associated breast inflammation
Dingzhi Wang1, Raymond N DuBois
1Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Abstract:
Subbaramaiah and colleagues present the first evidence indicating that a cyclooxygenase-2-prostaglandin E(2)-aromatase pathway promotes obesity-associated inflammation in women's breast tissues. Their findings shed new light on obesity-associated inflammation in general and provide a rationale for developing effective chemopreventive and therapeutic strategies targeting this pathway for obese women with breast inflammation and patients with hormone-dependent breast cancer.
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