Related Experiment Video
Updated: May 22, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
Published on: June 14, 2016
Obscured meshwork structure after treatment for heart failure: a case study
Taku Rokutanda1, Ikuo Misumi, Yousuke Hanaoka
1Internal Medicine, Kumamoto Saisyunsou Hospital, Japan.
This case report details an elderly heart failure patient whose left ventricular (LV) noncompaction became obscured after treatment. This suggests a potential mechanism for resolving LV noncompaction in heart failure patients.
Area of Science:
- Cardiology
- Cardiac Imaging
- Heart Failure Research
Background:
- Left ventricular (LV) noncompaction is a rare congenital cardiomyopathy characterized by prominent trabeculae and deep intertrabecular recesses.
- Heart failure management often involves improving cardiac function and remodeling.
- The dynamic changes in LV noncompaction morphology in response to heart failure treatment are not well understood.
Observation:
- An 87-year-old male patient presented with heart failure.
- Transthoracic echocardiography revealed diffuse mild left ventricular hypokinesis and apical LV noncompaction.
- Three-dimensional echocardiography confirmed a prominent trabecular meshwork.
Findings:
- Following successful heart failure treatment, a significant decrease in LV end-systolic dimension was observed.
- Remarkably, the prominent trabeculae appeared to converge and become less distinct (obscured) during end-systole.
- This dynamic change suggests that LV noncompaction morphology can be altered by effective heart failure therapy.
Implications:
- This case highlights a potential mechanism for the resolution or obscuring of LV noncompaction in the context of heart failure treatment.
- Further research may elucidate the prognostic significance of these dynamic echocardiographic changes in LV noncompaction.
- Understanding these mechanisms could lead to novel therapeutic strategies for cardiomyopathies.
More Related Videos
07:10Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
Published on: May 16, 2021
12:15Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
Published on: February 8, 2022
Related Concept Videos
Heart Failure II: Pathophysiology
Mitral Regurgitation IV: Nursing Management
Pathophysiology of Heart Failure