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Vaibhav Agarwal1, Mayank Bansal
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Uttar Pradesh, India. vaibhav@gmail.com
Recent Patents on Drug Delivery & Formulation
|May 15, 2012
Summary
Conventional drug delivery systems fail to account for the body's natural cycles. Chronomodulated dosage forms offer a solution by releasing medication in sync with circadian rhythms, improving treatment efficacy.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Chronopharmacology
Background:
- Conventional dosage forms do not align with the body's dynamic physiological rhythms, leading to suboptimal therapeutic outcomes.
- Disease states and drug responses often exhibit fluctuations tied to the body's daily (circadian) cycles.
- Zero-order drug release from traditional forms is inadequate for conditions influenced by biological timing.
Purpose of the Study:
- To review the potential of chronomodulated dosage forms for various pathological conditions.
- To summarize recent research and granted patents in the field of advanced drug delivery.
- To provide insights into proprietary techniques and marketed formulations for developing novel dosage forms.
Main Methods:
- Literature review of scientific publications and patent databases.
- Analysis of research focusing on chronomodulated drug release systems.
- Compilation of information on existing and emerging drug delivery technologies.
Main Results:
- Chronomodulated dosage forms can mimic the body's natural secretion cycles for targeted drug release.
- These advanced systems offer a promising approach to manage diseases influenced by circadian rhythms.
- The review highlights innovations and patented technologies in pulsed drug delivery.
Conclusions:
- Chronomodulated drug delivery systems represent a significant advancement over conventional forms.
- These systems have the potential to revolutionize treatment by aligning drug release with physiological needs.
- Further research and development in this area can lead to more effective and personalized therapies.
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