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Updated: May 22, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
The nervous system's potential role in multiple sclerosis associated bone loss
Sowmya Josyula1, Bijal K Mehta, Yuval Karmon
1Dept. of Neurology, SUNY Buffalo, 100 High Street, Buffalo, NY 14203, USA.
Abstract:
Osteoporosis is a degenerative bone disease that causes significant morbidity and mortality in multiple sclerosis (MS) patients; the pathogenesis of this disease being poorly understood in the context of MS. Osteoporosis is seen more frequently in MS patients than in healthy controls matched for age and sex. Extensively studied factors, including impaired ambulation and the use of steroids, do not appear to completely account for the phenomenon. This review summarizes common risk factors, physiologic and genetic, that may contribute to the etiology and progression of osteoporosis in MS patients as well as providing insight into nervous system control of bone metabolism and homeostasis.
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