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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Thirty years after the Cuban hemorrhagic dengue epidemic of 1981
1Pedro Kourí Tropical Medicine Institute, PAHO/WHO Collaborating Center for the Study and Control of Dengue, Havana, Cuba.
Insights
Cuba experienced a major dengue hemorrhagic fever epidemic in 1981. Decades of surveillance and research have largely prevented its return, though isolated outbreaks still occur.
Area of Science:
- * Tropical Medicine
- * Epidemiology
- * Infectious Disease Control
Background:
- * The 1981 dengue hemorrhagic fever epidemic in Cuba was the first reported in the Americas.
- * This epidemic resulted in over 344,000 cases and 158 deaths.
- * Cuba has maintained a dengue-free status for 30 years post-epidemic, despite sporadic outbreaks.
Purpose of the Study:
- * To review the 1981 dengue hemorrhagic fever epidemic in Cuba.
- * To present laboratory surveillance data.
- * To discuss related research findings.
Main Methods:
- * Review of historical epidemic data.
- * Analysis of laboratory surveillance records.
- * Synthesis of research outcomes related to dengue control.
Main Results:
- * The 1981 epidemic significantly impacted Cuba, with a high burden of severe cases.
- * Sustained surveillance and control efforts have been effective in preventing widespread resurgence.
- * Isolated transmission events indicate ongoing challenges in complete eradication.
Conclusions:
- * Effective public health strategies, including surveillance and research, are crucial for managing dengue.
- * Cuba's experience offers valuable insights into long-term dengue prevention.
- * Continued vigilance is necessary to address the persistent threat of dengue transmission.
Abstract:
In 1981, Cuba reported the first hemorrhagic dengue epidemic in the Americas, with 344,203 cases, including 10,312 severe and very severe cases, resulting in 158 deaths. In the 30 years following the epidemic, surveillance, control and research have kept Cuba dengue free; although isolated, interrupted epidemics and transmissions have been reported. In this article, we summarize issues of interest regarding the 1981 epidemic, as well as laboratory surveillance data and various related research results.
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