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Gender differences in accessory connections location: an Israeli study.
Edo Y Birati1, Michael Eldar, Bernard Belhassen
1Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ebirati@hotmail.com
Summary
Gender influences accessory connection (AC) location, with females showing a higher prevalence of right free wall ACs and males a higher prevalence of right anteroseptal ACs. These findings suggest a potential genetic influence on AC formation.
Area of Science:
- Cardiology
- Electrophysiology
- Genetics
Background:
- Accessory connections (AC) are implicated in cardiac arrhythmias.
- Emerging evidence suggests a genetic component in the development of ACs.
Purpose of the Study:
- To investigate potential gender-based differences in the anatomical distribution of ACs.
- To analyze AC location in a large cohort undergoing radiofrequency ablation (RFA).
Main Methods:
- Retrospective analysis of 804 patients undergoing RFA for single ACs.
- Data collected from two Israeli electrophysiology (EP) centers between 1992 and 2009.
- Comparison of AC locations between male and female patient groups.
Main Results:
- Right free wall ACs were more common in females (13%) than males (7.2%).
- Right anteroseptal ACs were more frequent in males (8.4%) than females (4.4%).
- Left free wall and posteroseptal AC locations showed no significant gender difference.
Conclusions:
- Significant gender-specific differences in AC location were observed in the Israeli population.
- Females are more likely to have right free wall ACs, while males are more likely to have right anteroseptal ACs.
- These location patterns support the hypothesis of a genetic role in AC pathogenesis.
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